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The molecular interactions between hosts, vectors and pathogens drive the etiology of infectious diseases. At first sight, the Guillain-Barré and Alpha-Gal syndromes have quite different etiologies but, as proposed here, a closer look into the immune response to galactose-containing oligosaccharide structures that characterizes these two diseases reveals striking commonalities. In this Opinion paper, we address the main molecular drivers of two apparently unrelated diseases, and how the characterization of the immune response and immunological tolerance would advance the control and prevention of these diseases.
Guillain-Barré and Alpha-gal Syndromes: Saccharides-induced Immune Responses
Iván PACHECO, PhD Student, University of Castilla-La Mancha, Ciudad Real, Sanidad y Biotecnología (SaBio)
IJMS, Free Full-Text
Guillain–Barré syndrome (Case 14) - Neuromuscular Disease
IJMS, Free Full-Text
Marinela CONTRERAS, PhD Juan de La Cierva Incorporación, PhD, Spanish National Research Council, Madrid, CSIC, Instituto de Investigación en Recursos Cinegéticos
Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies
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Publications Database - Alpha-gal Information